Tottenham Hotspur steamed into the top four with Harry Kane marking his 100th Premier League appearance with a double in a 4-1 thrashing of Watford on Sunday.
Arsenal laboured to their second win of the season with a highly-charged 1-0 victory against 10-man Newcastle United at St James' Park on Saturday.
West Ham United eased into the quarter-finals of the FA Cup with a 5-1 romp at second-tier Blackburn Rovers on Sunday.
Pogba suffered the injury in United's 3-0 Champions League win over Basel this month.
After seven consecutive league defeats, and one point from the last 30 on offer, had plunged Villa into crisis and cost Tim Sherwood his job, the former European champions produced a gritty display to frustrate City.
Factbox on Jose Mourinho, who was named manager of Tottenham Hotspur on Wednesday
Holders and Premier League leaders Arsenal will be at home to Championship (second tier) Burnley in the fourth round of the FA Cup after most of the big guns avoided top flight opponents in Monday's draw.
Manchester's police commissioner demanded an inquiry into the 'fiasco' of a fake bomb left behind from a training exercise at Old Trafford that forced the abandonment on Sunday of a Premier League soccer match.
The following are talking points from the Premier League weekend:
Premier League newcomers Watford suffered a League Cup upset in a 1-0 loss at Preston North End while five-times champions Aston Villa overcame plucky Notts County 5-3 after extra-time to reach the third round on Tuesday.
Liverpool's dream run was demolished in the most unlikely fashion by strugglers Watford on Saturday in what must be considered the most extraordinary reverse of the entire Premier League season. On the evening when the European champions were expected to complete the best sequence in the history of English football's top-flight with a 19th straight league victory, they were instead hammered 3-0 by the team lying one from bottom. Images from the EPL matches played on Saturday.
Wayne Rooney scored two first half goals to help send Manchester United to a 4-1 win over a spirited Aston Villa on Saturday, temporarily lifting the gloom surrounding David Moyes' dismal first term in charge.
Chelsea scored a second successive win over a newly-promoted side when they beat Leicester City 2-0 at Stamford Bridge on Saturday thanks to second-half goals from Diego Costa and Eden Hazard.
Chelsea are now 11 points ahead of Manchester City who have 13 games left to play and while Italian Conte is too cagey to start proclaiming his side yet, only a monumental loss of form can deny them the title.
Two big derbies and an eventful weekend of football awaits us all...
Stoke City manager Mark Hughes says he will not contest the Football Association's misconduct charge against him after he was sent off in Saturday's 4-0 Premier League defeat by Tottenham Hotspur.
Images from the English Premier League matches played on Saturday
The Belgian international has scored 13 league goals this season, four in the Champions League and four in the FA Cup, but has been criticised for not being effective against the bigger teams in England.
Premier League clubs West Bromwich Albion and Watford were knocked out in the League Cup second round by lower-league opponents on Tuesday as a strong Liverpool side crushed championship Burton Albion 5-0.
The Singapore government on Wednesday conveyed to the Indian High Commissioner its strong objection to Delhi Chief Minister Arvind Kejriwal's comments about a 'Singapore variant' of COVID-19, the Ministry of External Affairs (MEA) said.
IMAGES from soccer matches played in the EPL, La Liga and Serie A on Tuesday.
Chelsea made light of striker Diego Costa's absence to extend their lead at the top of the Premier League to seven points with a 3-0 win at champions Leicester City.
Images from the EPL matches played on Saturday
Leicester City's win over Newcastle on Monday not only sent them five points clear of Tottenham Hotspur at the top of the Premier League, it effectively ended the challenge of Manchester City and Arsenal.
The club anthem Blue is the Colour resounded around a joyful Stamford Bridge and champagne flowed as Chelsea clinched their first Premier League title for five years with a typically stubborn 1-0 victory over Crystal Palace on Sunday.
Juergen Klopp has said his Liverpool team must be prepared to play ugly football to secure Champions League qualification following the injury to productive forward Sadio Mane ahead of Wednesday's Premier League clash against Bournemouth.
Chelsea ran riot at Swansea City, scoring four times before halftime on the way to a 5-0 win that sent Jose Mourinho's side five points clear in the Premier League on Saturday.
Premier League champions Leicester City must pick themselves up to rediscover the winning habit and get their season back on track, winger Marc Albrighton has said.
New manager David Moyes has criticised the series of fixtures Manchester United have been handed at the start of the new season, hinting it is a deliberate ploy by the Premier League to give them a tough opening.
Still shaking off the rust from a 15-month doping ban and a string of nagging injuries, the 30-year-old Sharapova needed all her skill, determination and two hours and 44 minutes to snatch victory in front of a packed Arthur Ashe stadium.
The real head turners at Met Gala 2019.
Photos from the English Premier League matches played on Saturday
However, experienced goalkeeper Joe Hart and Arsenal midfielder Jack Wilshere were both omitted from a squad announced on Wednesday via a social media video featuring young recreational players from around the country shouting out the names.
The Premier League kicked off in unique fashion on Saturday as an own goal by Tottenham Hotspur's Kyle Walker gave Manchester United a 1-0 victory in an undistinguished season opener at Old Trafford.
McTominay injury takes gloss of vibrant United display
Manchester should brace itself for some fascinating local derbies if Jose Mourinho joins United, midfielder Bastian Schweinsteiger said on Wednesday. The Germany international declined to comment on reports that the former Chelsea and Real Madrid manager had agreed terms with United to succeed the sacked Louis van Gaal. However, he said every player would want to work under the Portuguese coach who will go head-to-head with Pep Guardiola who has already agreed to join rivals Manchester City.
But for third-placed Spurs, who trail leaders Manchester City and Liverpool by five points, this may prove to be a loss that leaves them with too much ground to make up.
Cardiff had lost six of their previous seven games but, knowing that anything but a victory would probably end their survival hopes after one season in the top flight, overcame a strong Brighton start to play with growing confidence and fully deserved their victory.
Following is a match by match look at the English Premier League's weekend fixtures:
Jack Wilshere and Harry Kane have been recalled to the England squad for Friday's World Cup qualifier against Scotland and a friendly against Spain, the FA announced on Sunday.
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